Interventional Radiology - Original Article
Study on the effect of chemoembolization combined with microwave ablation for the treatment of hepatocellular carcinoma in rats
Institute for Diagnostic and Interventional Radiology, Frankfurt University Hospital, Frankfurt/Main, Gemany
Department of Radiology, Union Hospital, Huazhong University of Science and Technology, Wuhan, PR China
Department of Visceral Surgery, Frankfurt University Hospital, Frankfurt/Main, Germany
Institute for Diagnostic and Interventional Radiology, Frankfurt University Hospital, Frankfurt/Main, Germany; Department of Radiology, Alexandria University School of Medicine, Alexandria, Egypt
Institute for Diagnostic and Interventional, Radiology Frankfurt University Hospital, Frankfurt/Main, Germany; Department of Radiology, Cairo University School of Medicine, Cairo, Egypt
Diagn Interv Radiol ; : -
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PURPOSE: We aimed to evaluate the combining effects of transarterial chemoembolization (TACE) and open local thermal microwave ablation (MWA) in a hepatocellular carcinoma animal model.
METHODS: Tumor cubes were implanted into the liver of 30 male inbred ACI rats. Groups of 10 animals were treated at 13 days (TACE or MWA) and 16 days (MWA) postimplantation with combined therapy (study group A) of TACE (0.1 mg mitomycin C; 0.1 mg iodized oil; 5.0 mg degradable starch microspheres) and MWA (2450 Mhz; 45 s; 35 W), TACE (control group B) or MWA (control group C) alone. At day 12 and day 25 tumor size was measured via magnetic resonance imaging and the relative growth ratio was calculated. Hepatic specimens were immunohistochemically examined for the expression of vascular endothelial growth factor (VEGF).
RESULTS: Mean growth rates were 1.34±0.19 in group A, 3.19±0.13 in group B, and 4.18±0.19 in group C. Compared with control groups B and C, tumor growth rate in group A was significantly inhibited (P < 0.01). The VEGF-antibody reaction in peritumoral tissue (staining intensity at portal triad, percent antibody reaction and staining intensity at central vein) was significantly lower in group A compared with group B (P < 0.01). No significant difference between group A and group C could be observed.
CONCLUSION: This investigation shows improved results of TACE followed by MWA as treatment of hepatocellular carcinoma in a rat model, compared with single therapy regimen regarding the inhibition of growth rate and reduction of VEGF-level in peritumoral tissue.