E-ISSN 1305-3612
Modality-based (US, CT, MRI, PET-CT) Imaging - Original Article
ARFI shear-wave elastography with simulation of acute urinary tract obstruction in an ex vivo porcine kidney model
1 Division of Pediatric Radiology, Clinic of Diagnostic and Interventional Radiology University of Heidelberg School of Medicine, Heidelberg, Germany  
2 Department of Visceral and Transplantation Surgery , University of Heidelberg School of Medicine, Heidelberg, Germany  
3 Department of Visceral and Transplantation Surgery ,University of Heidelberg School of Medicine, Heidelberg, Germany  
4 Division of Pediatric Radiology, Clinic of Diagnostic and Interventional Radiology, University of Heidelberg School of Medicine, Heidelberg, Germany  
5 Clinic I, Center for Pediatrics and Adolescent Medicine, University of Heidelberg School of Medicine, Heidelberg, Germany  
6 Division of Pediatric Nephrology, Clinic I, Center for Pediatrics and Adolescent Medicine, University of Heidelberg School of Medicine, Heidelberg, Germany  
Diagn Interv Radiol 2018; 24: 308-315
DOI: 10.5152/dir.2018.17353
Abstract

PURPOSE: We aimed to evaluate if acoustic radiation force impulse (ARFI) shear-wave elastography (SWE) can detect change of parenchymal stiffness in an ex vivo porcine kidney model of acute urinary tract obstruction.



METHODS
: A total of 20 heparinized pig kidneys were investigated at 10 intrapelvic hydrostatic pressure steps (0–90 mmHg). SWE (ARFI; Virtual TouchTM IQ, Siemens) measurements were taken at three different measuring regions and in two measuring sequences using a linear ultrasonography probe (9L4, Siemens). Median values of 10 shear-wave speed (SWS) measurements were calculated for each pressure step. Logarithmic transformed median SWS values were analyzed in a linear mixed model.


RESULTS
: SWS increased significantly with increasing intrapelvic pressure. Median SWS for all kidneys in both measuring sequences and all measuring regions was 1.47 m/s (interquartile range [IQR], 0.38 m/s) at 0 mmHg, 1.94 m/s (IQR, 0.42 m/s) at 30 mmHg, 2.07 m/s (IQR, 0.43 m/s) at 60 mmHg, 2.24 m/s (IQR, 0.49 m/s) at 90 mmHg. The correlation between pelvic pressure increase and median SWS values for the central parenchyma was significantly higher compared with the peripheral parenchyma.


CONCLUSION
: Acutely increased renal pelvic pressure correlates with increasing SWS values in ARFI elastography in an ex vivo porcine kidney model.


You may cite this article as
: Muttray J, Mehrabi A, Hafezi M, et al. ARFI shear-wave elastography with simulation of acute urinary tract obstruction in an ex vivo porcine kidney model. Diagn Interv Radiol 2018; 24:308-315.

 

Key Words
Authors
All
Author's Corner
Reviewer's Corner
Survey
Copyright © Turkish Society of Radiology | Latest Update: 06.09.2018