E-ISSN 1305-3612
Abdominal Imaging - Review
Genotype-phenotype correlations in hepatocellular adenoma: an update of MRI findings
1 Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands  
2 Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands  
3 Department of Radiology, Medical Center Zuiderzee, Lelystad, the Netherlands.  
4 Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands  
Diagn Interv Radiol 2014; 20: 193-199
DOI: 10.5152/dir.2013.13315

Hepatocellular adenoma (HCA) is a generally benign liver tumor with the potential for malignancy and bleeding. HCAs are categorized into four subtypes on the basis of genetic and pathological features: hepatocyte nuclear factor 1α-mutated HCA, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA. Magnetic resonance imaging (MRI) plays an important role in the diagnosis, subtype characterization, and detection of HCA complications; it is also used to differentiate HCA from focal nodular hyperplasia. In this review, we present an overview of the genetic abnormalities, oncogenesis, and typical and atypical MRI findings of specific subtypes of HCA using contrast-enhanced MRI with or without hepatobiliary contrast agents (gadobenate dimeglumine and gadoxetate disodium). We also discuss their different management implications after diagnosis.

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