ISSN 1305-3825 | E-ISSN 1305-3612
General Radiology - Original Article
Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy
1 Department of Radiology, Dokuz Eylül University School of Medicine, İzmir, Turkey  
2 Division of Endocrinology, Dokuz Eylül University School of Medicine, İzmir, Turkey  
3 Department of Pediatric Genetics, Dokuz Eylül University School of Medicine, İzmir, Turkey  
4 Division of Pediatric Neurology, Dr. Behçet Uz Children’s Hospital, İzmir, Turkey  
5 Division of Endocrinology, Ege University School of Medicine, İzmir, Turkey  
6 Division of Endocrinology, İstanbul University School of Medicine, İstanbul, Turkey  
7 Divisions of Endocrinology, Dokuz Eylül University School of Medicine, İzmir, Turkey  
8 Department of Biochemistry, Atatürk Training and Research Hospital, İzmir, Turkey  
9 Division of Pediatric Endocrinology, Uludağ University School of Medicine, Bursa, Turkey  
10 Department of Pathology, Dokuz Eylül University School of Medicine, İzmir, Turkey  
11 Department of Internal Medicine, Dokuz Eylül University School of Medicine, İzmir, Turkey  
12 Department of Medical Genetics, Ege University School of Medicine, İzmir, Turkey  
Diagn Interv Radiol 2017; 23: 428-434
DOI: 10.5152/dir.2017.17019
Abstract

PURPOSE: We aimed to investigate residual adipose tissue with whole-body magnetic resonance imaging to differentiate between subtypes of lipodystrophy.

 

METHODS: A total of 32 patients (12 with congenital generalized lipodystrophy [CGL], 1 with acquired generalized lipodystrophy [AGL], 12 with familial partial lipodystrophy [FPLD], and 7 with acquired partial lipodystrophy [APL]) were included.

 

RESULTS: Despite generalized loss of metabolically active adipose tissue, patients with CGL1 caused by AGPAT2 mutations had a significant amount of residual adipose tissue in the scalp, earlobes, retro-orbital region, and palms and soles. No residual adipose tissue was noted particularly in the head and neck, palms and soles in CGL2 caused by BSCL2 mutations. CGL4 caused by mutations in the PTRF gene was characterized with well-preserved retro-orbital and bone marrow fat in the absence of any visible residual adipose tissue in other areas. No residual adipose tissue was observed in AGL. Despite loss of subcutaneous fat, periarticular adipose tissue was preserved in the lower limbs of patients with FPLD. Retro-orbital adipose tissue was surprisingly preserved in APL, although they lacked head and neck fat.

 

CONCLUSION: Lipodystrophies are a heterogeneous group of disorders characterized by generalized or partial loss of adipose tissue, which can be congenital or acquired. Our results suggest that residual adipose tissue characteristics can help distinguish different subtypes of lipodystrophy.

 

 

You may cite this article as: Altay C, Seçil M, Demir T, et al. Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy. Diagn Interv Radiol 2017; 23:428–434.

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