Diagnostic and Interventional Radiology
Abdominal Imaging - Original Article

A new proposal of an ultrasonic imaging model for predicting overall and progression-free survival in patients with primary hepatocellular carcinoma

1.

Department of Ultrasound, Shangluo Central Hospital, Shaanxi; People’s Republic of China

2.

Department of Utrasound, Xianyang Maternal and Child Health Hospital, Shaanxi; People’s Republic of China

Diagn Interv Radiol 2022; 28: 301-311
DOI: 10.5152/dir.2022.20783
Read: 287 Downloads: 120 Published: 01 July 2022

PURPOSE
We aimed to develop models for predicting overall survival (OS) and progression-free survival (PFS) of patients with primary hepatocellular carcinoma (HCC).

METHODS
Clinicopathological characteristics and laboratory information of patients were collected. We retrospectively analyzed presurgical data of 216 patients with primary HCC. The random forest and least absolute shrinkage and selection operator regression models were used to select features. We established prognostic models for predicting OS and PFS of primary liver cancer using ultrasonic imaging as well as clinical and pathological features. Accuracy of the models was evaluated using area under the curve, C index, and calibration curves, whereas their clinical application value was assessed using decision curve analysis.

RESULTS
Models for predicting OS and PFS were established based on ultrasonic imaging accessible features. The models showed excellent accuracy and prognosis prediction of OS and PFS in patients with primary HCC.

CONCLUSION
The established models based on factors such as aspartate aminotransferase platelet ratio index, Child-Turcotte-Pugh grade, tumor grade, hepatitis B virus-DNA, the intensity of ultrasound enhancement at the portal stage, lymphocyte/monocyte ratio, portal hypertension, gender, stage, the beginning time of ultrasonic contrast, and the total grade of ultrasonic enhancement can effectively predict OS and PFS of primary HCC.

You may cite this article as: Li X-Y, Wang L-L. A new proposal of an ultrasonic imaging model for predicting overall and progression-free survival in patients with primary hepatocellular carcinoma. Diagn Interv Radiol. 2022;28(4):301-311.

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