Diagnostic and Interventional Radiology
Modality-based (US, CT, MRI, PET-CT) Imaging - Review

Proton density fat fraction: magnetic resonance imaging applications beyond the liver

1.

Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey

2.

Department of Radiology, Hacettepe University, School of Medicine, Ankara, Turkey

Diagn Interv Radiol 2022; 28: 83-91
DOI: 10.5152/dir.2021.21845
Read: 624 Downloads: 210 Published: 01 January 2022

Magnetic resonance imaging-proton density fat fraction (MRI-PDFF) is an emerging quantitative imaging biomarker that accurately measures the fat fraction of tissue by correcting factors influencing magnetic resonance signal intensity. Beyond fat quantification, it also measures R2* which is a direct measure of iron concentration. The utilization of MRI-PDFF in liver diseases is well established. In the present review, we focused on applications of MRI-PDFF in different body areas including pancreas, bone, muscle, spleen, testis, visceral, and subcutaneous adipose tissue. Future studies can enable tracking of quantitative fat fraction changes in different organs simultaneously, which can be critical in understanding fat metabolism. 

You may cite this article as: Idilman IS, Yildiz AE, Karaosmanoglu AD, Ozmen MN, Akata D, Karcaaltincaba M. Proton density fat fraction: magnetic resonance imaging applications beyond the liver. Diagn Interv Radiol. 2022;28(1):83-91.

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