Diagnostic and Interventional Radiology
Interventional Radiology - Review

Value of pre-intervention CT perfusion imaging in acute ischemic stroke prognosis


Neurovascular Imaging Laboratory, Ingham Institute for Applied Medical Research, Clinical Sciences Stream, Sydney, Australia


University of New South Wales (UNSW), South Western Sydney Clinical School, NSW, Australia


Department of Neurology & Neurophysiology, Liverpool Hospital & South West Sydney Local Health District (SWSLHD), Sydney, Australia


Ingham Institute for Applied Medical Research, Stroke & Neurology Research Group, Sydney, Australia


NSW Brain Clot Bank, NSW Health Statewide Biobank and NSW Health Pathology, Sydney, NSW, Australia


Thrombolysis and Endovascular WorkFLOw Network (TEFLON), Sydney, Australia

Diagn Interv Radiol 2021; 27: 774-785
DOI: 10.5152/dir.2021.20805
Read: 298 Downloads: 49 Published: 01 November 2021

Noninvasive imaging plays an important role in acute stroke towards diagnosis and ongoing management of patients. Systemic thrombolysis and endovascular thrombectomy (EVT) are proven treatments currently used in standards of care in acute stroke settings. The role of computed tomography angiography (CTA) in selecting patients with large vessel occlusion for EVT is well established. However, the value of CT perfusion (CTP) imaging in predicting outcomes after stroke remains ambiguous. This article critically evaluates the value of multimodal CT imaging in early diagnosis and prognosis of acute ischemic stroke with a focus on the role of CTP in delineating tissue characteristics, patient selection, and outcomes after reperfusion therapy. Insights on various technical and clinical considerations relevant to CTP applications in acute ischemic stroke, recommendations for existing workflow, and future areas of research are discussed.

You may cite this article as: Katyal A, Bhaskar S. Value of pre-intervention computed tomography perfusion imaging in acute ischemic stroke prognosis. Diagn Interv Radiol 2021; 27:774–785.

EISSN 1305-3612