E-ISSN 1305-3612
Oncologic Imaging - Review
Proton magnetic resonance spectroscopy in oncology: the fingerprints of cancer?
1 Department of Radiology, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain  
2 Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Northwood, Middlesex, United Kingdom  
3 Department of Radiology, Hospital Clínic Barcelona, Barcelona, Spain  
4 Department of Radiology, Clínica Girona and Hospital Santa Caterina, Girona, Spain  
5 Clinica Las Nieves, Sercosa, Jaén, Spain; Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA  
6 Mestrelab Research, Santiago de Compostela, Spain  
Diagn Interv Radiol 2016; 22: 75-89
DOI: 10.5152/dir.2015.15009

Abnormal metabolism is a key tumor hallmark. Proton magnetic resonance spectroscopy (1H-MRS) allows measurement of metabolite concentration that can be utilized to characterize tumor metabolic changes. 1H-MRS measurements of specific metabolites have been implemented in the clinic. This article performs a systematic review of image acquisition and interpretation of 1H-MRS for cancer evaluation, evaluates its strengths and limitations, and correlates metabolite peaks at 1H-MRS with diagnostic and prognostic parameters of cancer in different tumor types.

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